Plague Inc. Tips: Where to Start

In Plague, Inc. you are tasked with creating a plague and spreading it across the world, infecting and wiping out the human race. But with scientists working tirelessly to develop a cure, and with different growing conditions all over the world, it's harder than you might think. That's why we decided to create a Plague Inc. advice guide, to give you sage advice on how to take your plague from a small batch of infected humans to a global pandemic.


In this guide, we'll give you tips and tricks from Plague Inc., explaining how Evolution Points work and how best to earn them, as well as some key tips for getting started and choosing a good location. Whether creating a chaotic virus, infecting the globe with sheer force, or choosing a subtle and devious parasite, insidiously stitching itself through the population.


Plague Inc. has a simple theme and direct conflict, as you try to infect the world before your time is up and a cure is found. But what makes the game special is how it plays with the formula to always keep you on your toes.

everything in our Plague Inc. tips guide:

plague inc. game: how to play

Here we'll walk you through the game and help you acclimatize:

  • Your main task in Plague Inc. is to spread your plague as far as possible
  • The infection stat, which is helpfully displayed on the evolution page, is the most important factor in achieving this
  • Resistances will also play a role in spreading your plague. Russia is freezing, so cold resistance gives it an advantage; first-world countries use antibiotics and other treatments, so appropriate resistance is virtually essential for effective spread in this country.
  • The best way to spread is to select the most immediately advantageous evolutions at the beginning and the transition to niche cases last.
  • The key is to spend your points appropriately, adapt your plague to the spread, and deal with the situation you're facing.

Plague Inc. Tips: Where to Start



plague inc. tips and tricks

Getting started in Plague Inc. can be difficult, so here are some tips to help:

  • It's in the genes, baby: when creating your plague, it's best to double down on a unique strength (Patho-stasis for mushrooms, for example) or shore up a weak area, like weather resistance or spread bonuses for environments. These aren't unlocked by default and are overkill on easier difficulty settings, but are crucial on Brutal difficulty and higher.
  • Location, Location, Location: A player's starting location is very important, as the spread pattern and rate is highly dependent on your home country's location and climate. It's a bit of a Plague Inc. meme that Greenland and Madagascar end up being roadblocks once they close the borders, snatching your victory away from you. When selecting a country of departure, aim for land spread, with some islands, and flights to nearby neighbors
  • Evolution Points: Infecting new countries awards evolution points, as does reaching certain demographic milestones. These are key elements of strategy, as is forming an effective build path based on the nature of your disease and random events in your game. Generally, maximizing transmission and resistances early is a must, with a late game pivot to lethality
  • Time your evolution: It's important to ration your evolution points, as perks cost progressively more to evolve with each one you choose. Points are also getting harder and harder to earn, so timing your progress is valuable. Parasites can afford to be stealthy and cluster dots for ages, but viruses have spontaneous traits added by runaway mutations, so they have to move fast. Timing is everything

Plague Inc. Tips: Where to Start


plague inc. DNA points: how to get them?

DNA Points are an important part of Plague Inc. Here's how to get them:


  • Infect a larger raw number of people
  • Kill more hosts
  • Expand into new countries
  • Devolution of traits to recover points

plague inc. types: what are the best types of plague?

Choosing your plague is an important step at Plague Inc. Here are the different types:

  • Bacteria: This is the default plague type in the middle of the road. It is average in terms of strengths and weaknesses
  • Parasite: This one starts out rather noticeable and deadly, but needs to evolve quickly to blend in. Once it does, however, it is stealthy only and can often infect the entire world before the search for a cure progresses.
  • Viruses: These constantly mutate new symptoms throughout the game, and you have to pay to remove them. It's high profile and chaotic, but can be very powerful, as mutated symptoms mean more DNA points to spend elsewhere
  • Mushroom: This slow plague can use points to spread to new lands via its burst spore upgrade
  • Nano-Virus: This plague starts the game with a worldwide effort to find a cure, but it has stronger stats to compensate for that, and unique upgrades to slow down the search.
  • Bio-Hazard: This plague increases in lethality over time and must be reset multiple times to prevent the transmission rate from falling below the kill count.
  • Prions: This subtle plague is very difficult to cure but also exceptionally difficult to spread.
  • Neutrax Worm: This plague significantly alters gameplay, changes the behavior of its human host, allowing you to send flights full of infected passengers to chosen countries
  • Necroa: This zombie-like virus can reanimate corpses to spread disease further
  • Simian: this is the closest to the Planet of the Apes you will get, as this plague causes the ape population and intelligence to increase
  • Shadow Plague: This plague of vampires hunts and converts humans with an elaborate system of abilities and weaknesses

Plague Inc. Tips: Where to Start



plague inc. to unlock: how to find secrets in the game?

You need to unlock some of the rarest plague types, cheat codes, and genes by playing Plague Inc. Here's how:

  • You unlock diseases by completing the previous disease normally or better
  • You unlock the collective pool genes, by simply beating the game with any flail
  • You unlock rarer diseases like Neutrax, Necroa, Simian, and Shadow Plague once you beat the game on hard difficulty with each base disease
  • You unlock cheat codes by beating the game on mega brutal difficulty with each disease

plague inc. MULTIPLAYER: can I play with friends?

Yes, but only in two players. Each of you chooses a secret starting country and continues to spread until one or the other is cured or everyone is infected and passed on, in which case the disease with the highest count. You can also trigger healing research offensively to ruin your opponent's day.

And here's our Plague Inc. tips guide! If you want more games like Plague Inc., be sure to check out our list of the best mobile strategy games.

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